无码欧美成人av天堂456软件,大胆日本熟妇XXXX,9277在线观看免费播放,4p三个男人让我爽了一夜

全、新、優(yōu)、品、好四大特點(diǎn)：

蛋白酶激活受體-2抗體品牌 全：公司提供上萬種產(chǎn)品，涵蓋了生物試劑，elisa試劑盒，標(biāo)準(zhǔn)品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細(xì)胞等，基本上各種科研所需產(chǎn)品在我司都能找到。

新：產(chǎn)品更新速度較快，基本上每周都有新產(chǎn)品出現(xiàn)。

優(yōu)：產(chǎn)品質(zhì)量好，投訴比較少。

好：我公司具有優(yōu)質(zhì)的技術(shù)團(tuán)隊(duì)，產(chǎn)品一旦售出，實(shí)驗(yàn)過程中遇到困難可提供在線技術(shù)咨詢。使您使用產(chǎn)品時(shí)沒有任何的后顧之憂。

蛋白酶激活受體-2抗體品牌 英文名稱  Anti-PAR-2

中文名稱  蛋白酶激活受體-2抗體品牌 

別    名 F2RL1; Gpcr11; GPR11; PAR-2; Proteinase-activated receptor 2; coagulation factor II (thrombin) receptor-like 1.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Rabbit

產(chǎn)品類型   一抗  

研究領(lǐng)域     細(xì)胞膜受體 G蛋白偶聯(lián)受體

蛋白分子量  predicted molecular weight: 40kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PAR2 (101-150aa)

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

蛋白酶激活受體-2抗體品牌 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 The Proteinase-activated receptor 2 (PAR2) is a member of the proteinase-activated receptor subfamily. It is activated through proteolytic exposure of an occult tethered ligand by trypsin and trypsin-like proteases. This is in contrast to other members of the subfamily which are activated by the protease thrombin. PAR2 has been implicated in acute inflammatory response, asthma, and pain transmission. PAR2 expression has been documented in the periphery. ESTs have been isolated from adrenal, brain, breast, heart/melanocyte/uterus, kidney, lung, and vessel libraries.

Coagulation factor II (thrombin) receptor-like 1 (F2RL1)is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq].

Function : Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.

Subunit : Interacts with TLR4, COPS5 and TMED2. Interacts with GNAQ, GNA11, GNA12, GNA13 and GNA14.

Tissue Specificity : Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle.

Post-translational modifications : A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Activating serine proteases include trypsin, mast cell tryptase, coagulation factors VII and Xa, myeloblastin/PRTN3 and membrane-type serine protease 1/ST14. Proposed subsequent cleaveage by serine proteases is leading to receptor deactivation and include neutrophil elastase and cathepsin G. At least in part, implicated proteases are also shown to activate the receptor; the glycosylation status of the receptor is thought to contribute to the difference. In addition to conventional trypsin-like proteases is proposed to be activated by other proteases and glycosidases derived from bacteria, fungi and insects: serine protease allergens such as dust mite Der p3 and Der p9 and mold Pen c13, Porphyromonas gingivalis arginine-specific (trypsin-like) cysteine proteinases called gingipains, Streptomyces griseus exogenous chitinase, and an Alternaria alternata aspartate protease. Cleavage by the Alternaria alternata aspartate protease generates non-conventional processed forms.

N-glycosylated and sialylated.

Multiple phosphorylated on serine and threonine residues in the cytoplasmic region upon receptor activation; required for receptor desensitization and recruitment of beta-arrestin.

Monoubiquitinated by CBL at the plasma membrane and in early endosomes; not required for receptor endocytosis but for translocation to late endosomes or lysosomes. Deubiquitination involves STAMBP and USP8; required for lysosomal trafficking and receptor degradation.

Similarity : Belongs to the G-protein coupled receptor 1 family.

Database links : UniProtKB/Swiss-Prot: P55085.1

PAR2也是細(xì)胞表面受體，通過G蛋白影響細(xì)胞功能，PAR蛋白全稱為蛋白酶活化受體（Protease-activated receptors），是獨(dú)立家族的G蛋白偶聯(lián)受體，經(jīng)研究認(rèn)為PAR2與，實(shí)體等密切相關(guān)。

實(shí)驗(yàn)流程：

正在熱銷的相關(guān)產(chǎn)品：

Anti-Ezrin/Radixin/FITC 熒光素標(biāo)記埃茲蛋白抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Anti-NAP1 /FITC 熒光素標(biāo)記核小體組裝蛋白1抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Rhesus antibody Rh C17orf59 17號(hào)染色體開放閱讀框59抗體 規(guī)格 0.2ml

BRCA1(Breast cancer susceptbility gene 1)(mouse rat) 癌易感基因1抗原(小鼠 大鼠) 0.5mg

HRP2 英文名稱： 衍生生長因子2抗體 0.2ml

Rhesus antibody Rh ROC1/RNF75 環(huán)指蛋白75抗體 規(guī)格 0.2ml

Anti-NAP1 /FITC 熒光素標(biāo)記核小體組裝蛋白1抗體IgGMulti-class antibodies規(guī)格： 0.2ml

Beta-DF ELISA Kit 大鼠β-防御素Multi-class antibodies規(guī)格： 48T

Anti-Phospho-TNK1 (Tyr277) 磷酸化非受體型酪氨酸蛋白激酶Tnk1抗體Multi-class antibodies規(guī)格： 0.1ml

Rhesus antibody Rh GLP-1(1G9) GLP-1單克隆抗體 規(guī)格 0.1ml

NT-proBNP(Human N-terminal pro-brain natriuretic peptide) ELISA KIT 人N端前腦素 96T

Neuropeptide S 英文名稱： 神經(jīng)肽S抗體 0.2ml

Anthrax 英文名稱： 炭疽桿菌抗體 0.2ml

Anti-Phospho-TNK1 (Tyr277) 磷酸化非受體型酪氨酸蛋白激酶Tnk1抗體Multi-class antibodies規(guī)格： 0.1ml

ODC(Human Ornithine decarboxylase) ELISA Kit 人鳥氨酸脫羧酶Multi-class antibodies規(guī)格： 48T

Anti-NOS-2/iNOS 合成酶-2抗體(誘導(dǎo)型)Multi-class antibodies規(guī)格： 0.1ml

Rhesus antibody Rh IKK gamma/IKBKG KB抑制蛋白激酶γ抗體 規(guī)格 0.2ml

LFA-3/CD58(Mouse lymphocyte function associated antigen 3) ELISA Kit 小鼠淋巴細(xì)胞功能相關(guān)抗原3 96T

phospho-PIK3R2(Tyr467) 英文名稱： 磷酸化磷脂酰肌醇激酶p85β抗體 0.1ml

Connexin-40 英文名稱： 間隙連接蛋白40抗體 0.1ml

Anti-NOS-2/iNOS 合成酶-2抗體(誘導(dǎo)型)Multi-class antibodies規(guī)格： 0.1ml

CL-0345HB611(人細(xì)胞)5×106cells/瓶×2

MFI2 Others Mouse 小鼠 MFI2 / CD228 / melanoansferrin 人細(xì)胞裂解液 (陽性對(duì)照)

小鼠肺大動(dòng)脈平滑肌細(xì)胞完全培養(yǎng)基 100mL

C3H/10T1/2, Clone 8小鼠胚胎成纖維細(xì)胞 C3H/10T1/2, Clone 8 mouse embryonic fibroblast MEM培養(yǎng)基(GIBCO)+10%FBS

IL1B Protein Cynomolgus 重組食蟹猴 IL-1 beta / IL1B 蛋白

NCI-H520(人肺鱗癌細(xì)胞) 5×106cells/瓶×2 T/G HA-VSMC(人主動(dòng)脈平滑肌細(xì)胞)

CL-0342H4-II-E-C3(大鼠細(xì)胞 )5×106cells/瓶×2

PDGFRB Others Human 人 PDGFRB / PDGFR-1 / CD140b 人細(xì)胞裂解液 (陽性對(duì)照)

人肺微內(nèi)皮細(xì)胞總RNAHPMEC NA

HCC1937細(xì)胞，人癌細(xì)胞 鼠胸腺激酶缺陷細(xì)胞株,L-MTK細(xì)胞 原代細(xì)胞特制基礎(chǔ)無血清培養(yǎng)基Many types of cells包裝：500/100ml

M-NFS-60 (小鼠細(xì)胞G-CSF依賴性) 5×106cells/瓶×2

HDBEC adult Pellet 人皮膚內(nèi)皮細(xì)胞團(tuán)塊(成年捐獻(xiàn)者) > 1 mio.cells 間充質(zhì)干細(xì)胞軟骨細(xì)胞分化培養(yǎng)基MCDM-prf

蛋白酶激活受體-2抗體品牌 FCGR2A Others Human 人 CD32a / FCGR2A CHO細(xì)胞裂解液 (陽性對(duì)照)

CL-0058CCRF-CEM(人急性淋巴細(xì)胞)5×106cells/瓶×2

TUNEL色標(biāo)法細(xì)胞凋亡檢測試劑盒TUNEL

牛腎細(xì)胞;MDBK(BVDV-free) 鼠胚胎成纖維細(xì)胞，PA317細(xì)胞 MLA-144細(xì)胞，長臂猿

EB病毒轉(zhuǎn)化的人B淋巴細(xì)胞(拉祜族);KM9406

ELANE Others Mouse 小鼠 Neuophil Elastase / ELANE / ELA2 人細(xì)胞裂解液 (陽性對(duì)照)

技術(shù)外包服務(wù):

★蛋白酶激活受體-2抗體品牌 分子生物學(xué)：質(zhì)粒抽提、PCR、Q-PCR、RT-PCR、分子生物學(xué)：基因合成、引物合成、基因測序、載體構(gòu)建等

★蛋白工程：原核、哺乳動(dòng)物蛋白表達(dá)系統(tǒng)等

★病毒包裝：腺病毒、慢病毒等

★抗體工程：磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★細(xì)胞工程：細(xì)胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復(fù)、克隆形成)、細(xì)胞培養(yǎng)、細(xì)胞膜制備、穩(wěn)定細(xì)胞株構(gòu)建、細(xì)胞RNAi技術(shù)等等。