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凋亡誘導(dǎo)受體PLEKHG5抗體說(shuō)明書(shū) 英文名稱(chēng)  Anti-PLEKHG5

中文名稱(chēng)  凋亡誘導(dǎo)受體PLEKHG5抗體說(shuō)明書(shū) 

別    名 Apo 3; APO3; Apoptosis inducing receptor AIR; Apoptosis mediating receptor DR3; Apoptosis mediating receptor TRAMP; DDR3; Death domain receptor 3; DR3; DSMA 4; DSMA4; GEF 720; GEF720; Guanine nucleotide exchange factor 720; KIAA0720; LARD; Lymphocyte associated receptor of death; Novel PH domain containing protein; Pleckstrin homology domain containing family G member 5; Pleckstrin homology domain containing, family G (with RhoGef domain) member 5; PLEKHG 5; Putative NFkB activating protein; RP4 650H14.3; TNFRSF12; Tumor necrosis factor receptor superfamily member 25 precursor; WSL; WSL1.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來(lái)源  Rabbit

克隆類(lèi)型   polyclonal

交叉反應(yīng)   Human

產(chǎn)品類(lèi)型   一抗  

研究領(lǐng)域    神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué)

蛋白分子量  predicted molecular weight: 43kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human PLEKHG5 (25-100aa)

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

凋亡誘導(dǎo)受體PLEKHG5抗體說(shuō)明書(shū) 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 PLEKHG5 is predominantly expressed in the peripheral nervous system and brain. PLEKHG5 localizes to the cytoplasm, however when cells are stimulated, PLEKHG5 is found near the perinuclear regions. PLEKHG5 contains the highly-conserved DH-PH module which is considered to be the signature motif of the Dbl family of guanine nucleotide exchange factors (GEFs). PLEKHG5 activates the NFkB signaling pathway and may be involved in the control of neuronal cell differentiation. It has been suggested that mutations in the PLEKHG5 gene may lead to autosomal recessive distal spinal muscular atrophy (DSMA). Four isoforms of PLEKHG5 exists due to alternative splicing events.

Function : Receptor for TNFSF12/APO3L/TWEAK. Interacts directlywith the adapter TRADD. Mediates activation of NF-kappa-B andinduces apoptosis. May play a role in regulating lymphocytehomeostasis.

Subunit : Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signalingcascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.

Subcellular Location : Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2:Cell membrane; Single-pass type I membrane protein. Isoform 9: Cell membrane; Single-pass type I membrane protein. Isoform 11: Cell membrane; Single-pass type I membrane protein. Isoform 3:Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Isoform 6: Secreted. Isoform 7: Secreted.Isoform 8: Secreted. Isoform 10: Secreted. Isoform 12: Secreted

Post-translational modifications : Glycosylated (Probable).

Similarity : Contains 1 death domain.

Contains 4 TNFR-Cys repeats.

Database links : UniProtKB/Swiss-Prot: Q93038.2

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