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谷氨酸受體2C抗體規(guī)格 英文名稱  Anti-NR2C/NMDAR2C

中文名稱  谷氨酸受體2C抗體規(guī)格 

別    名 N-Methyl-d-Asprtate receptor 2C; Glutamate Receptor Ionotropic N Methyl D Aspartate 2C; GRIN2C; N Methly D Aspartate Receptor Channel Subunit Epsilon 3; N Methyl D Aspartate Receptor Subtype 2C; NR2C; NMDE3_HUMAN.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig

產(chǎn)品類型   一抗  

研究領(lǐng)域    神經(jīng)生物學(xué)

蛋白分子量  predicted molecular weight: 132kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human NR2C intermedial

亞    型  IgG

純化方法   affinity purified by Protein A

儲(chǔ) 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

谷氨酸受體2C抗體規(guī)格 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 NMDAR2C is mainly expressed in brain, predominantly in the cerebellum. This protein is a NMDA receptor subtype of the glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium.

Function : NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.Subunit : Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B).Subcellular Location : Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.Tissue Specificity : Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.Similarity : Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.Database links : UniProtKB/Swiss-Prot: Q14957.3谷氨酸受體2C（NR2C 又稱作Glutamate Receptor NMDAR2C;Glutamate receptor ；N-Methyl-d-Asprtate receptor-2C）是脊椎動(dòng)物型神經(jīng)傳遞的主要介質(zhì)。在突觸可塑性及大腦學(xué)習(xí)及方面起關(guān)鍵作用。

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