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神經(jīng)生長因子受體抗體品牌
  • 品牌:上海莼試
  • 產(chǎn)地:進口、國產(chǎn)
  • 貨號:CS9875
  • 發(fā)布日期: 2018-12-26
  • 更新日期: 2025-05-16
產(chǎn)品詳請
產(chǎn)地 進口、國產(chǎn)
品牌 上海莼試
保存條件 Store at -20 °C
貨號 CS9875
應(yīng)用范圍 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
CAS編號
抗體名 Anti-NGFR/p75NTR
克隆性
靶點 詳見說明書
適應(yīng)物種 詳見說明書
形態(tài) 詳見說明書
宿主 詳見說明書
亞型 IgG
標識物 詳見說明書
濃度 1mg/1ml%
免疫原 KLH conjugated synthetic peptide derived from human NGFR C-terminus

神經(jīng)生長因子受體抗體品牌 英文名稱  Anti-NGFR/p75NTR

中文名稱  神經(jīng)生長因子受體抗體品牌 

     Gp80 LNGFR; ngfrp75; Low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; NGF receptor; p75 ICD; CD271; CD271 antigen; Gp80 LNGFR; Low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Nerve growth factor receptor; Nerve growth factor receptor TNFR superfamily member 16; NGF receptor; NGFR; p75 ICD; p75 Neurotrophin receptor; p75 NTR; TNFR Superfamily Member 16; TNFRSF16; Tumor necrosis factor receptor superfamily member 16.

產(chǎn)品屬性:

      1mg/1ml

規(guī)   0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig

產(chǎn)品類型   一抗  

研究領(lǐng)域    細胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo)

蛋白分子量  predicted molecular weight: 44kDa 

       Lyophilized or Liquid

  KLH conjugated synthetic peptide derived from human NGFR C-terminus

      IgG

純化方法   affinity purified by Protein A

   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

神經(jīng)生長因子受體抗體品牌 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

(石蠟切片需做抗原修復(fù)) 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells. NGF is important for the development, differentiation and survival of a variety of neuronal and non-neuronal cells. Its action is mediated by binding to two distinct receptors, the high affinity p140 and low affinity p75. p75NGFR binds neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, and NT-6. p75NGFR belongs to the TNF-R superfamily and is reported to mediate NGF-induced apoptosis.

Function : Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.Subunit : Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1 (By similarity). Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with NRADD.Subcellular Location : Membrane; Single-pass type I membrane protein.Post-translational modifications : N- and O-glycosylated.Phosphorylated on serine residues.Similarity : Contains 1 death domain.Contains 4 TNFR-Cys repeats.神經(jīng)生物學(xué)相關(guān)蛋白(Neurobiology)NGFR神經(jīng)生長因子受體又稱:CD271存在與細胞上的與神經(jīng)生長因子相結(jié)合并相互作用的蛋白質(zhì)因子,屬一型跨膜TNF受體超家族糖蛋白,它可與NGF, BDNF, NT-3, NT-4 結(jié)合,根據(jù)與神經(jīng)生長因子的結(jié)合力速度及親和力可分為高親和力和低親和力兩種NGFR。此抗體識別分子量為47kDa低親和力的NGFR.NGF-R也稱為低親和神經(jīng)生長因子受體,屬1型跨膜TNF受體超家族。

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