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產(chǎn)地 | 進(jìn)口、國(guó)產(chǎn) |
品牌 | 上海莼試 |
保存條件 | Store at -20 °C |
貨號(hào) | CS9878 |
應(yīng)用范圍 | WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
CAS編號(hào) | |
抗體名 | Anti-NHE1/APNH1 |
克隆性 | |
靶點(diǎn) | 詳見(jiàn)說(shuō)明書(shū) |
適應(yīng)物種 | 詳見(jiàn)說(shuō)明書(shū) |
形態(tài) | 詳見(jiàn)說(shuō)明書(shū) |
宿主 | 詳見(jiàn)說(shuō)明書(shū) |
亞型 | IgG |
標(biāo)識(shí)物 | 詳見(jiàn)說(shuō)明書(shū) |
濃度 | 1mg/1ml% |
免疫原 | KLH conjugated synthetic peptide derived from human NHE1 |
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鈉氫通道蛋白抗體規(guī)格 英文名稱 Anti-NHE1/APNH1
中文名稱 鈉氫通道蛋白抗體規(guī)格
別 名 APNH; APNH1; FLJ42224; Na Li countertransporter; Na+ H+ antiporter amiloride-sensitive; Na+ H+ antiporter; Na+ H+ exchanger 1; NHE1; OTTHUMP00000004468; SLC9A1; Sodium hydrogen exchanger 1; solute carrier family 9; Solute carrier family 9 member 1; Solute carrier family 9 sodium hydrogen exchanger isoform 1 antiporter Na+ H+ amiloride sensitive; SL9A1_HUMAN; Sodium / Hydrogen Exchanger 1.
產(chǎn)品屬性:
濃 度 1mg/1ml
規(guī) 格 0.2ml/200μg
抗體來(lái)源 Rabbit
克隆類型 polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit
產(chǎn)品類型 一抗
研究領(lǐng)域 心 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 通道蛋白 轉(zhuǎn)運(yùn)蛋白
蛋白分子量 predicted molecular weight: 91kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human NHE1
亞 型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
鈉氫通道蛋白抗體規(guī)格 產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 NHE1 ( Na+/H+ Exchanger) is maintains in the cell one of environment main cell membrane protein, its main function is adjusts in the cell the pH value, makes it to maintain in the physiological scope. In the cell the pH value change, is direct or the indirect influence cell growth splits, the multiplication and the differentiation, also affects the cell the death. activeness also affects the cell the migration and the tumor cell shift. At present the main direction is: Research digestive tract tumor cell shift.
Function : Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.Subunit : Oligomer (By similarity). Interacts with calmodulin and TESC. Interacts (via the juxtamembrane region of the cytoplasmic C-terminus domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner. Interacts with CHP2; the interaction occurs in a calcium-dependent manner.Subcellular Location : Membrane; Multi-pass membrane protein.Tissue Specificity : Kidney and intestine.Post-translational modifications : O-glycosylated.Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1 (By similarity).Similarity : Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.Database links : UniProtKB/Swiss-Prot: P19634.2通道蛋白(Channel Protein)鈉-氫交換蛋白(NHE: Na+/H+ Exchanger)是維持細(xì)胞內(nèi)環(huán)境的主要細(xì)胞膜蛋白質(zhì)之一,它的一個(gè)主要功能是調(diào)節(jié)細(xì)胞內(nèi)pH值,使之保持在生理范圍之內(nèi)。細(xì)胞內(nèi)pH值的變化,直接或間接的影響細(xì)胞的生長(zhǎng)分裂、增殖和分化,也影響細(xì)胞的死亡。鈉-氫交換蛋白質(zhì)的活性還影響細(xì)胞的移動(dòng)和細(xì)胞的轉(zhuǎn)移。目前主要方向是:研究細(xì)胞轉(zhuǎn)移。
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