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神經(jīng)生長因子β抗體說明書 英文名稱  Anti-NGF-β

中文名稱  神經(jīng)生長因子β抗體說明書 

別    名 Beta nerve growth factor; NGF-beta; NGF β; β NGF; β-NGF; Beta nerve growth factor precursor; Beta NGF; HSAN5; MGC161426; MGC161428; Nerve growth factor beta; Nerve growth factor beta polypeptide; Nerve growth factor beta subunit; NGF B; NGFB; NID67; NGF beta; NGF-B.

產(chǎn)品屬性：

濃    度  1mg/1ml

規(guī) 格  0.1ml/100μg 0.2ml/200μg

抗體來源  Rabbit

克隆類型   polyclonal

交叉反應(yīng)   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit

產(chǎn)品類型   一抗  

研究領(lǐng)域    發(fā)育生物學(xué) 神經(jīng)生物學(xué)

蛋白分子量  predicted molecular weight: 13kDa 

性    狀   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human NGF beta C-terminus

亞    型  IgG

純化方法   affinity purified by Protein A

儲 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

神經(jīng)生長因子β抗體說明書 產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

產(chǎn)品介紹 Neurotrophins function to regulate naturally occuring cell death of neurons during development .The prototype neurotrophin is nerve growth factor (NGF),originally discovered in the 1950s as a soluble peptide promoting the survival of and veurite outgrowth from, sympathetic ganglia. More recently,three additional structurally homologous neurotrophic factor have been identified.These include brain-derived neurotrophic factor (BDNF), neurotrophic-3 (NT-3) neurotrophic-4(NT-4), also designated NT-5. These neurous neurotrophic stimulate the in vitro survival of distinct but partilly overlapping populations of neurons. The Trk A receptor is the preferential receptor for NGF, but also binds NT-3and NT-4. The Trk B receptor binds equally well both BDNF and NT-4, and to a lesser extent NT-3, while the Trk C receptor only binds NT-3.

Function : Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.Subunit : Homodimer.Subcellular Location : Secreted.DISEASE : Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.Similarity : Belongs to the NGF-beta family.Database links : UniProtKB/Swiss-Prot: P01138.3神經(jīng)生長因子-β(NGF-β)屬于一種對神經(jīng)元的生長、分化、延長存活期有促進作用的神經(jīng)生長因子家族。此抗體識別分子量為29kDa 的NGF蛋白。神經(jīng)生長因子(Nerve Growth Factor,NGF)是最早被發(fā)現(xiàn)、兼有神經(jīng)元營養(yǎng)和促突觸生長雙重生物學(xué)功能的一種細(xì)胞,可.

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